Project 1
The Sleep, Physical Activity, Sedentary Behavior and Cognitive Function Project will integrate ambulatory measures of sleep health, physical activity and sedentary behavior from wearable sensors to assess the effects of these behaviors on cognitive outcomes and potential vascular mechanisms underlying these associations.
Overview
Poor sleep, sleep disorders, low levels of physical activity and sedentary behavior are common in older adults, and each has been associated with risk for Alzheimer’s disease and related dementias (ADRD). Yet, little is known regarding the joint effects and patterns of these behaviors on cognitive health.
Daily assessments in Project 1 include actigraphy-based measures (sleep quality, duration and timing, daytime napping, as well as physical activity and sedentary behavior) and oximetry on a single night to capture sleep disordered breathing (intermittent nocturnal hypoxemia).
Project 1 will use ambulatory measures to examine the independent and joint effects of sleep, physical activity and sedentary behavior on cognitive outcomes. Vascular and inflammatory mechanisms linking these behaviors to cognitive outcomes will be examined. Also explored will be whether racial/ethnic disparities in these health behaviors are related to disparities in ADRD.
To view the full abstract and further project details from NIH RePORTER, click here.